Inherited genetic factors play a role in the risk of many types of cancer, including breast cancer. Researchers have discovered a particular genetic variant associated with an increased risk of breast and other cancers. This variant is linked to tumours with numerous DNA alterations compared to normal cells in the body. Fortunately, previous research suggests that these tumours may respond well to immune-targeting therapies. This variant appears more frequently in Polynesian populations, and this research project seeks to understand its connection to breast cancer risk and its impact on tumour mutations among women in New Zealand.

The study will also examine how this variant interacts with other genes and whether it affects cancer risk following menopausal hormone therapy. This research could help identify if those with this genetic variant face a higher risk of breast cancer and if they are more likely to benefit from immunotherapy if cancer develops.

FIRST NAMED INVESTIGATOR: Associate Professor Anita Dunbier
HOST INVESTIGATOR: University of Otago