Investigating Genetic Drivers of Breast Cancer Risk and Response to Therapies
Inherited genetic factors play a role in the risk of many types of cancer, including breast cancer. Researchers have discovered a particular genetic variant associated with an increased risk of breast and other cancers. This variant is linked to tumours with numerous DNA alterations compared to normal cells in the body. Fortunately, previous research suggests that these tumours may respond well to immune-targeting therapies. This variant appears more frequently in Polynesian populations, and this research project seeks to understand its connection to breast cancer risk and its impact on tumour mutations among women in New Zealand.
The study will also examine how this variant interacts with other genes and whether it affects cancer risk following menopausal hormone therapy. This research could help identify if those with this genetic variant face a higher risk of breast cancer and if they are more likely to benefit from immunotherapy if cancer develops.
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From Evidence to Action: Expanding the ‘Not a One-Size-Fits-All’ Breast Cancer Screening Model for Aotearoa New Zealand.
Problem:Breast cancer screening in Aotearoa New Zealand does not benefit all women equally. Many cancers are still found outside the national screening programme, and Māori and Pacific women can fa...
Using Deep Learning And Digital Pathology To Intrinsically Subtype Breast Cancer
Problem:Traditional pathology uses microscopes to examine tissue slides, but this method can be slow and inconsistent, and not all patients can afford advanced molecular testing. Project:Digital pa...
“Shielding” Macrophages: Uncovering Immune-Mediated Chemoresistance in Triple-Negative Breast Cancer
ProblemTriple-negative breast cancer (TNBC) is one of the hardest types to treat and affects Māori and Pacific women more than others. Many patients with TNBC don’t fully respond to chemotherapy, a...
